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,This results in a significant loss of braking efficiency and can lead to partial or full loss of directional control.The British government first recognized the dangers of hydroplaning in the late 1950s.The Royal Air Force wanted to reduce the number of incidents they were experiencing under wet and standing water runway conditions.A study discovered that grooving and crowning runways improved the braking efficiency and drainage capabilities.NASA has graded the different types of runway surfaces based on runway texture (macrotexture), and the depth of grooves and crowning.Class 1 runway surfaces have the highest macrotexture depth values and Class 5 have the lowest macrotexture depth values.
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,Malawi.Malaysien.Malediven.Mali.Malta.Marshall-Inseln.Martinique.Mauretanien.Mauritius.Mexiko.It is the cultural aspect only that can help in communicating the message in the way it should be.Plus, it also helps in avoiding misunderstandings.Before beginning the translation work, it is essential for the translator to do some research on the lexical content and syntax of the target language along with the ideologies, value systems and ways of life in a given culture.This will help the translators to have an idea about the audience in both languages and different elements of the target language.
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,If both products come anywhere near to phase I results in larger registration trials, they will each represent major therapeutic advances.It is my experience that in cases in which two products using similar technology are commercialized, there is rarely, if ever, just one winner and one loser.ICT-107 can only work in a certain immune type (HLA A1 and A2 positive) and not in the rest of the glioblastoma population.In the phase II trial of ICT-107 that just completed enrollment, about 50% of patients were HLA A1/A2 positive suggesting that ICT-107 can only address half the patient population.I also see no reason why these products could not be used in sequence or perhaps in combination to improve results.
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